About Me
Mohammad Kamruzzaman obtained his BSc Honors and MSc degrees in Biochemistry and Molecular Biology from University of Dhaka, Bangladesh in 2015 and 2017, respectively. He started his career as a Research Officer at the International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b) in 2017. In 2019, Kamruzzaman was awarded a prestigious fellowship (D43TW005572) for an international research training program in vaccine development and public health from the National Institute of Health- Fogarty International Centre (NIH-FIC). During his fellowship at Massachusetts General Hospital (MGH), Harvard Medical School, USA, he focused on improving the cholera conjugate vaccine targeting VC O139 and gained valuable experience in vaccine development and public health research.
After completing his specialist training in infectious disease (2019-2020) at MGH, Kamruzzaman returned to his home country and rejoined icddr,b. Kamruzzaman has made significant contributions to ongoing COVID-19 research, including establishing a lentivirus-based pseudo-neutralization assay to determine the functional antibody responses in COVID-19 infected and vaccinated populations in Bangladesh. Over the last six years of his research journey, he has developed a strong background in infectious diseases, focusing primarily on host-pathogen interactions and immune responses, with a particular emphasis on enteric infections and development of vaccines protective against them. On September 02, 2023, he joined as a Lecturer in the Department of Biochemistry and Molecular Biology at Mawlana Bhashani Science and Technology University.
Research Interest
Mucosal immunology and vaccinology, Systems Biology
Professional & Other Experiences
1. Research Officer (Jun 2017-Jul 2019)- icddr,b
2. Research Fellow (Jul 2019-Aug 2020)- Harvard Medical School, Boston, USA
3. Research Officer (Sept 2020-Oct 2022)- icddr,b
4. Senior Research Officer (Nov 2022-Aug 2023)- icddr,b
5. Lecturer (Sept 2023-Present)- Department of Biochemistry and Molecular Biology, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902
Education
1. Bachelor of Science (BS): Biochemistry and Molecular Biology, University of Dhaka (2015)
2. Master of Science (MS): Biochemistry and Molecular Biology, University of Dhaka (2016)
Publications
2. Kelly, M., Janardhanan, J., Wagh, C., Verma, S., Charles, R. C., Leung, D. T., Kamruzzaman, M., Pansuriya, R. K., … & Ryan, E. T. (2024). Development of a Shigella conjugate vaccine targeting Shigella flexneri 6 that is immunogenic and provides protection against virulent challenge. Vaccine, 42(24), 126263.
3. Bernshtein, B., Kelly, M., Cizmeci, D., Zhiteneva, J. A., Macvicar, R., Kamruzzaman, M., ... & Ryan, E. T. (2024). Determinants of immune responses predictive of protection against shigellosis in an endemic zone: a systems analysis of antibody profiles and function. The Lancet Microbe. 100889.
4. Nobel, F. A., Kamruzzaman, M., Jebin, R. A., Uddin, M. N., Ruhee, N. N., Babu, G., & Islam, M. J. (2024). Revealing biomarkers and major pathways between SARS-CoV-2 and SARS-like viruses using transcriptomics analysis. Human Gene, 40, 201292.
5. Nobel, F. A., Kamruzzaman, M., Asaduzzaman, M., Uddin, M. N., Ahammad, H., Hasan, M. M., ... & Islam, M. J. (2024). Identification of Differentially Expressed Genes and Protein-Protein Interaction in Patients with COVID-19 and Diabetes Peripheral Neuropathy: A Bioinformatics and System Biology Approach. Cureus, 16(4).
6. Dash, P., Hakim, A., Akter, A., Banna, H.A., Kaisar, M.H., Aktar, A., Jahan, S.R., Ferdous, J., Basher, S.R., Kamruzzaman, M., … & Qadri, F. (2024). Cholera toxin and O-specific polysaccharide immune responses after oral cholera vaccination with Dukoral in different age groups of Bangladeshi participants. mSphere, 9(3), e00565-23.
7. Kelly, M., Jeon, S., Yun, J., Lee, B., Park, M., Whang, Y., Lee, C., Charles, R.C., Bhuiyan, T.R., Qadri, F., Kamruzzaman, M., ... & Ryan, E. T. (2023). Vaccination of Rabbits with a Cholera Conjugate Vaccine Comprising O-Specific Polysaccharide and a Recombinant Fragment of Tetanus Toxin Heavy Chain Induces Protective Immune Responses against Vibrio cholerae O1. The American Journal of Tropical Medicine and Hygiene, 109(5), p.1122.
8. Kaisar, M. H., Kelly, M., Kamruzzaman, M., Bhuiyan, T. R., Chowdhury, F., Khan, A. I., ... & Ryan, E. T. (2023). Comparison of O-specific polysaccharide responses in patients following infection with Vibrio cholerae O139 versus vaccination with a bivalent (O1/O139) oral killed cholera vaccine in Bangladesh. mSphere, 8(5), e00255-23.
9. Kelly, M., Mandlik, A., Charles, R.C., Verma, S., Calderwood, S.B., Leung, D.T., Biswas, R., Islam, K., Kamruzzaman, M., Chowdhury, F. ... & Ryan, E. T. (2023). Development of Shigella conjugate vaccines targeting Shigella flexneri 2a and S. flexneri 3a using a simple platform-approach conjugation by squaric acid chemistry. Vaccine, 41(34), pp.4967-4977.
10. Nizam, N. N., Mahmud, S., Ark, S. A., Kamruzzaman, M., & Hasan, M. K. (2023). Bakuchiol, a natural constituent and its pharmacological benefits. F1000Research, 12.
11. Jones, F. K., Bhuiyan, T. R., Muise, R. E., Khan, A. I., Slater, D. M., Hutt Vater, K. R., Chowdhury, F., Kelly, M., Xu, P., Kováč, P., Biswas, R., Kamruzzaman, M., Ryan, E. T., … & Azman, A. S. (2022). Identifying recent cholera infections using a multiplex bead serological assay. mBio, 13(6), e01900-22.
12. Akhtar, M., Basher, S. R., Nizam, N. N., Kamruzzaman, M., Khaton, F., Banna, H. A., ... & Qadri, F. (2022). Longevity of memory B cells and antibodies, as well as the polarization of effector memory helper T cells, are associated with disease severity in patients with COVID-19 in Bangladesh. Frontiers in Immunology, 13, 1052374.
13. Rashidijahanabad, Z., Kelly, M., Kamruzzaman, M., Qadri, F., Bhuiyan, T. R., McFall-Boegeman, H., ... & Huang, X. (2022). Virus-like particle display of Vibrio cholerae O-specific polysaccharide as a potential vaccine against cholera. ACS infectious diseases, 8(3), 574-583.
14. Jeon, S., Kelly, M., Yun, J., Lee, B., Park, M., Whang, Y., Lee, C., Halvorsen, Y.-D., Verma, S., Charles, R. C., Harris, J. B., Calderwood, S. B., Leung, D. T., Bhuiyan, T. R., Qadri, F., Kamruzzaman, M., Cho, S., Vann, W. F., Xu, P., Kováč, P., Ganapathy, R., Lynch, J., & Ryan, E. T. (2021). Scalable production and immunogenicity of a cholera conjugate vaccine. Vaccine, 39(47), 6936-6946.
15. Hasan, M. K., Kamruzzaman, M., Manjur, O. H. B., Mahmud, A., Hussain, N., Mondal, M. S. A., ... & Rahman, A. (2021). Structural analogues of existing anti-viral drugs inhibit SARS-CoV-2 RNA dependent RNA polymerase: A computational hierarchical investigation. Heliyon, 7(3). 16. Charles, R.C., Kelly, M., Tam, J.M.,
Akter, A., Hossain, M., Islam, K., Biswas, R., Kamruzzaman, M., Chowdhury, F., Khan, A.I. ... & Ryan, E. T. (2020). Humans surviving cholera develop antibodies against Vibrio cholerae O-specific polysaccharide that inhibit pathogen motility. mBio, 11(6), pp.10-1128.
17. Iyer, A.S., Jones, F.K., Nodoushani, A., Kelly, M., Becker, M., Slater, D., Mills, R., Teng, E., Kamruzzaman, M., Garcia-Beltran, W.F. ... & Charles, R. C. (2020). Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients. Science immunology, 5(52), eabe0367.
18. Choudhury, T. Z., Kamruzzaman, M., & Islam, L. N. (2019). Investigation of the cellular and soluble markers of inflammation for the assessment of cardiovascular risk in patients with acute coronary syndrome in Bangladesh. International Journal of Electronic Healthcare, 11(1), 67-80.
19. Kamruzzaman, M., Choudhury, T. Z., Rahman, T., & Islam, L. N. (2019). A cross-sectional study on assessment of oxidative stress in coronary heart disease patients in Bangladesh. World Journal of Cardiovascular Diseases, 9(05), 331.
20. Hossain, T., Kamruzzaman, M., Choudhury, T. Z., Mahmood, H. N., Nabi, A. N., & Hosen, M. I. (2017). Application of the subtractive genomics and molecular docking analysis for the identification of novel putative drug targets against Salmonella enterica subsp. enterica serovar Poona. BioMed research international, 2017(1), 3783714.
2. Kamruzzaman M, Tanvir Hossain, Kabir T, Fatema N, Munni MA, Akhteruzzaman S, Hosen MI. Subtractive Genomics: A faster and specific approach to rectify the dead ends of drug development. Presented on DNA Day. Organized by Department of Genetic Engineering and Biotechnology, Dhaka University, April 25, 2016.