About Me
I am an Assistant Professor in the Department of Biochemistry and Molecular Biology at Mawlana Bhashani Science and Technology University, Tangail, Bangladesh. My academic journey began with a Bachelor of Science (B.S.) and Master of Science (M.S.) in Biochemistry and Molecular Biology from the University of Dhaka, where I graduated with first-class honors, securing the 6th position in my undergraduate cohort and earning the Dean's Award for academic excellence.
My research career spans over a decade, covering diverse areas in life sciences, including molecular epidemiology, heavy metal toxicity, neurodegenerative disorders, and hypertensive vascular diseases. I began as a Scientific Officer at the Columbia University Arsenic Research Project in Narayanganj, Bangladesh, where I worked for over five years under the indirect supervision of globally renowned scientists, including Prof. Habibul Ahasan and Prof. Joseph H. Graziano. This role honed my expertise in handling and processing human biospecimens and contributed to more than 15 publications in high-impact journals.
In 2015, I joined the International Centre for Diarrheal Disease Research, Bangladesh (icddr,b), as a Senior Research Officer. My work here focused on salinity in drinking water and its impact on kidney health, equipping me with skills in project development, laboratory setup, and management.
In 2016, I was awarded the prestigious Japanese Government Monbukagakusho Scholarship (MEXT) to pursue a Ph.D. at Juntendo University, Tokyo, Japan. My doctoral research, under the supervision of Prof. Yumiko Motoi and advisory support from Prof. Nobuta Hattori, focused on prion-like tau propagation and its inhibition, contributing to advancements in understanding dementia-related neurodegenerative disorders. My Ph.D. work was published in international journals, and I earned a Best Poster Presentation Award for my contributions.
After completing my Ph.D., I continued at Juntendo University as a Postdoctoral Fellow, where I explored the effects of physical exercise on miRNA expression and its potential to alleviate dementia-related comorbidities. This research resulted in a chapter contribution to Elsevier’s book on autophagy dysfunction in Alzheimer's and dementia.
My academic and research career is complemented by a strong teaching portfolio, where I actively guide both undergraduate and graduate students, alongside contributing to curriculum development and examination processes. Fluent in English, Bengali, and with basic proficiency in Japanese and Urdu, I aim to foster interdisciplinary collaboration and contribute meaningfully to advancements in biochemistry and molecular biology.
Research Interest
Neurology, Dementia, Alzheimer’s Disease, Molecular Epidemiology, Epigenetic
Professional & Other Experiences
1. Feb 2023 - Present
Assistant Professor, Department of Biochemistry and Molecular Biology, Mawlana Bhashani Science and Technology University, Tangail, Bangladesh
2. Apr 2021 - Feb 2023 (1 year 11 months)
Postdoctoral Fellow, Center for Genomic and Regenerative Medicine,Juntendo University, Tokyo, Japan.
3. Oct 2016 - Mar 2021 (4 years 6 months)
Graduate Student in the Department of Diagnosis, Treatment, and Prevention of Dementia, Juntendo University, Tokyo, Japan.
4. Sep 2015 - Sep 2016 (1 year 1 month)
Senior Research Officer, icddr, b
5. Dec 2009 - Sep 2015 (5 years 10 months)
Scientific Officer, Columbia-Chicago University Arsenic and Health Research Office in Bangladesh
Education
1. 2016 - 2021
Doctor of Philosophy – PhD in Medicine, Juntendo University, Tokyo, Japan
2. 2007 – 2008
Master’s of Science, Biochemistry and Molecular Biology, University of Dhaka, Bangladesh
3. 2001 – 2007
Bachelor's Science, Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh
4. Jul 1999 - Jun 2001
Higher Secondary School, Science, Birshreshtha Munshi Abdur Rouf Public College, Dhaka
5. Jan 1997 - Jun 1999
Birshreshtha Munshi Abdur Rouf Public College, Dhaka, Secondary School Certificate, Science
Publications
2.Mahmud, A. R., Ahammed, M. M., Islam, M., Nobel, F. A., Kamruzzaman, M., Uddin, M. N., & Islam, M. J. (2024). Age and Gender Disparities in Cancer Biomarker Expression: Insights from a Population-Based Investigation in Mymensingh District of Bangladesh. MBSTU Journal of Science and Technology, 10(1), 9-16.
3.Hossen, M. A., Yeasin, M. T., Hossain, M. A., Jahan, U. M. S., Rahman, M., Suvo, A. H., Sohel, M., Moli, M. A., Islam, M. K., & *Uddin, M. N. (2024). Exploring Potential Pathways and Biomarkers of Pancreatic Cancer Associated with Lynch Syndrome and Type 2 Diabetes: An Integrated Bioinformatics Analysis. Informatics in Medicine Unlocked, 101527.
4.Imtiaz, A., Shimonaka, S., Uddin, M. N., Elahi, M., Ishiguro, K., Hasegawa, M., Hattori, N., & Motoi,Y. (2024). Selection of lansoprazole from an FDA-approved drug library to inhibit the Alzheimer’s disease seed-dependent formation of tau aggregates. Frontiers in Aging Neuroscience, 16, 1368291.
5.Martinez-Morata, I., Parvez, F., Wu, H., Eunus, M., Uddin, M. N., Goldsmith, J., Ilievski, V., Slavkovich, V., Balac, O., Izuchukwu, C., & Glabonjat, R. A. (2024). Influence of folic acid and vitamin B12 supplementation on arsenic methylation: A double-blinded, placebo-controlled trial in Bangladeshi children. Environment International, 187, 108715.
6.Medina, S., Zhang, Q.-Y., Lauer, F. T., Santos-Medina, L. V., Factor-Litvak, P., Islam, T., Eunus, M., Rahman, M., Uddin, M. N., & Liu, K. J. (2024). Arsenic exposure is associated with alterations to multiple red blood cell parameters among adults in rural Bangladesh. Toxicology and applied pharmacology, 484, 116858.
7.Nobel, F. A., Kamruzzaman, M., Asaduzzaman, M., Uddin, M. N., Ahammad, H., Hasan, M. M., Kar, T. R., Juliana, F. M., Babu, G., & Islam, M. J. (2024). Identification of Differentially Expressed Genes and Protein-Protein Interaction in Patients With COVID-19 and Diabetes Peripheral Neuropathy: A Bioinformatics and System Biology Approach. Cureus, 16(4).
8.Nobel, F. A., Kamruzzaman, M., Jebin, R. A., Uddin, M. N., Ruhee, N. N., Babu, G., & Islam, M. J.(2024). Revealing biomarkers and major pathways between SARS-CoV-2 and SARS-like viruses using transcriptomics analysis. Human Gene, 40, 201292.
9.SHIMONAKA, S., IMTIAZ, A., UDDIN, M. N., SHIBA, M., ISHIGURO, K., MOTOI, Y., & HATTORI, N. (2024). The molecular pathology of tau strain and anti-aggregation strategy. Dementia Japan, 38(1), 123-130.
10.Abuawad AK, B. A., Navas-Acien A, Goldsmith J, Liu X, Hall MN, Ilievski V, Lomax-Luu AM, Parvez F, Shahriar H, Uddin MN, Islam T, Graziano JH, Gamble MV. (2023). Treatment Effects of Supplementation on Arsenic Methylation Indices and Metabolite Concentrations in Blood in a Bangladeshi Population. Environmental Health Perspectives, 131(3), 037015-037011-037011.
11.Uddin, M. N., Shimonaka, S., & Motoi, Y. (2022). Tau propagation and autophagy. In Autophagy Dysfunction in Alzheimer's Disease and Dementia (pp. 173-194). Elsevier. 12.Winardi, W., Wahyuni, H., Hidayat, M., Wirawan, A., Nurwidya, F., Uddin, M. N., & Yusup, M. (2022). Challenges on tuberculosis care in health care facilities during COVID-19 pandemic: Indonesian perspective. Narra J, 2(2).
13.Abuawad, A., Spratlen, M. J., Parvez, F., Slavkovich, V., Ilievski, V., Lomax-Luu, A. M., Saxena, R., Shahriar, H., Uddin, M. N., & Islam, T. (2021). Association between body mass index and arsenic methylation in three studies of Bangladeshi adults and adolescents. Environment International, 149, 106401.
14.Bozack, A. K., Howe, C. G., Hall, M. N., Liu, X., Slavkovich, V., Ilievski, V., Lomax-Luu, A. M., Parvez, F., Siddique, A. B., & Shahriar, H. Uddin, M. N. (2021). Betaine and choline status modify the effects of folic acid and creatine supplementation on arsenic methylation in a randomized controlled trial of Bangladeshi adults. European journal of nutrition, 60, 1921-1934.
15.Saxena, R., Liu, X., Navas-Acien, A., Parvez, F., LoIacono, N. J., Islam, T., Uddin, M. N., Ilievski, V., Slavkovich, V., & Balac, O. (2021). Nutrition, one-carbon metabolism and arsenic methylation in Bangladeshi adolescents. Environmental Research, 195, 110750.
16.Uddin, M. N., Elahi, M., Shimonaka, S., Kakuta, S., Ishiguro, K., Motoi, Y., & Hattori, N. (2021). Strain-specific clearance of seed-dependent tau aggregation by lithium-induced autophagy. Biochemical and Biophysical Research Communications, 543, 65-71.
17.Uddin, M. N., Elahi, M., Shimonaka, S., Kakuta, S., Ishiguro, K., Motoi, Y., & Hattori, N. (2020). Clearance of seed-dependent tau aggregation by lithium-induced autophagy: Implications of strain-specificity: Developing topics. Alzheimer's & Dementia, 16, e047342
18.Bozack, A. K., Hall, M. N., Liu, X., Ilievski, V., Lomax-Luu, A. M., Parvez, F., Siddique, A. B., Shahriar, H., Uddin, M. N., & Islam, T. (2019). Folic acid supplementation enhances arsenic methylation: results from a folic acid and creatine supplementation randomized controlled trial in Bangladesh. The American journal of clinical nutrition, 109(2), 380-391.
19.Chen, Y., Wu, F., Liu, X., Parvez, F., LoIacono, N. J., Gibson, E. A., Kioumourtzoglou, M.-A., Levy, D., Shahriar, H., & Uddin, M. N. (2019). Early life and adolescent arsenic exposure from drinking water and blood pressure in adolescence. Environmental Research, 178, 108681.
20.Naser, A. M., Doza, S., Rahman, M., Ahmed, K. M., Gazi, M. S., Alam, G. R., Karim, M. R., Khan, G. K., Uddin, M. N., & Mahmud, M. I. (2019). Sand barriers around latrine pits reduce fecal bacterial leaching into shallow groundwater: a randomized controlled trial in coastal Bangladesh. Environmental science & technology, 53(4), 2105-2113.
21.Naser, A. M., Rahman, M., Unicomb, L., Doza, S., Gazi, M. S., Alam, G. R., Karim, M. R., Uddin, M. N., Khan, G. K., & Ahmed, K. M. (2019). Drinking water salinity, urinary macro-mineral excretions, and blood pressure in the southwest coastal population of Bangladesh. Journal of the American Heart Association, 8(9), e012007.
22.Wasserman, G. A., Liu, X., Parvez, F., Chen, Y., Factor-Litvak, P., LoIacono, N. J., Levy, D., Shahriar, H., Uddin, M. N., & Islam, T. (2018). A cross-sectional study of water arsenic exposure and intellectual function in adolescence in Araihazar, Bangladesh. Environment International, 118, 304-313.
23.Howe, C. G., Liu, X., Hall, M. N., Ilievski, V., Caudill, M. A., Malysheva, O., Lomax-Luu, A. M.,Parvez, F., Uddin, M.N., Siddique, A. B., & Shahriar, H. (2017). Sex-specific associations between one-carbon metabolism indices and posttranslational histone modifications in arsenic-exposed Bangladeshi adults. Cancer Epidemiology, Biomarkers & Prevention, 26(2), 261-269.
24.Naser, A. M., Rahman, M., Unicomb, L., Doza, S., Ahmed, K. M., Uddin, M. N., Selim, S., Gribble,M. O., Anand, S., & Clasen, T. F. (2017). Drinking water salinity and kidney health in southwest coastal Bangladesh: baseline findings of a community-based stepped-wedge randomised trial. The Lancet, 389, S15.
25.Naser, A. M., Unicomb, L., Doza, S., Ahmed, K. M., Rahman, M., Uddin, M. N., Quraishi, S. B., Selim, S., Shamsudduha, M., & Burgess, W. (2017). Stepped-wedge cluster-randomised controlled trial to assess the cardiovascular health effects of a managed aquifer recharge initiative to reduce drinking water salinity in southwest coastal Bangladesh: study design and rationale. BMJ Open, 7(9), e015205.
26.Hall, M. N., Howe, C. G., Liu, X., Caudill, M. A., Malysheva, O., Ilievski, V., Lomax-Luu, A. M.,Parvez, F., Siddique, A. B., & Shahriar, H. Uddin, M. N. (2016). Supplementation with folic acid, but not creatine, increases plasma betaine, decreases plasma dimethylglycine, and prevents a decrease in plasma choline in arsenic-exposed Bangladeshi adults. The Journal of nutrition, 146(5), 1062-1067.
27.Howe, C. G., Liu, X., Hall, M. N., Slavkovich, V., Ilievski, V., Parvez, F., Siddique, A. B., Shahriar, H., Uddin, M. N., & Islam, T. (2016). Associations between blood and urine arsenic concentrations and global levels of post-translational histone modifications in Bangladeshi men and women. Environmental Health Perspectives, 124(8), 1234-1240.
28.Sanchez, T. R., Levy, D., Shahriar, M. H., Uddin, M. N., Siddique, A. B., Graziano, J. H., Lomax- Luu, A., van Geen, A., & Gamble, M. V. (2016). Provision of well-water treatment units to 600 households in Bangladesh: A longitudinal analysis of urinary arsenic indicates fading utility. Science of the Total Environment, 563, 131-137.
29.Wasserman, G. A., Liu, X., Parvez, F., Factor-Litvak, P., Kline, J., Siddique, A. B., Shahriar, H., Uddin, M. N., van Geen, A., & Mey, J. L. (2016). Child intelligence and reductions in water arsenic and manganese: a two-year follow-up study in Bangladesh. Environmental Health Perspectives, 124(7), 1114-1120.
30.Peters, B. A., Hall, M. N., Liu, X., Parvez, F., Sanchez, T. R., van Geen, A., Mey, J. L., Siddique, A. B., Shahriar, H., & Uddin, M. N. (2015). Folic acid and creatine as therapeutic approaches to lower blood arsenic: a randomized controlled trial. Environmental Health Perspectives, 123(12), 1294-1301.
31.Peters, B. A., Hall, M. N., Liu, X., Parvez, F., Siddique, A. B., Shahriar, H., Uddin, M. N., Islam, T., Ilievski, V., & Graziano, J. H. (2015). Low-dose creatine supplementation lowers plasma guanidinoacetate, but not plasma homocysteine, in a double-blind, randomized, placebo controlled trial. The Journal of nutrition, 145(10), 2245-2252.
32.Chervona, Y., Hall, M. N., Arita, A., Wu, F., Sun, H., Tseng, H.-C., Ali, E., Uddin, M. N., Liu, X., & Zoroddu, M. A. (2012). Associations between arsenic exposure and global posttranslational histone modifications among adults in Bangladesh. Cancer Epidemiology, Biomarkers & Prevention, 21(12), 2252-2260.